van Oudenaarde K1, Jobke B2, Oostveen AC3, Marijnissen AC4, Wolterbeek R5, Wesseling J4, Bierma-Zeinstra SM6,7, Bloem HL8, Reijnierse M8, Kloppenburg M9.Predictive value of MRI features for development of radiographic osteoarthritis in a cohort of participants with pre-radiographic knee osteoarthritis-the CHECK study. Rheumatology (Oxford). 2017 Jan;56(1):113-120. doi: 10.1093/rheumatology/kew368. [Epub 2016 Oct 25] Link to this article

Fernández-Moreno M1, Soto-Hermida A1, Vázquez-Mosquera ME1, Cortés-Pereira E1, Relaño S2, Hermida-Gómez T1, Pértega S3, Oreiro-Villar N1, Fernández-López C1, Garesse R4,5, Blanco FJ1, Rego-Pérez I1.Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study. Ann Rheum Dis. 2016 Dec 5. pii: annrheumdis-2016-210131. doi: 10.1136/annrheumdis-2016-210131. Link to this article

Jadran Botterman, Christina Bode, Liseth Siemons, Mart A.F.J. van de Laar and Joost DekkerExploring Fatigue Trajectories in Early Symptomatic Knee and Hip Osteoarthritis: 6-year Results from the CHECK Study. The Journal of Rheumatology July 2016, 43 (7) 1413-1420; DOI: Link to this article

Bastick AN, Verkleij SP, Damen J, Wesseling J, Hilberdink WK, Bindels PJ, Bierma-Zeinstra SM. Defining hip pain trajectories in early symptomatic hip osteoarthritis – 5 year results from a nationwide prospective cohort study (CHECK). Osteoarthritis Cartilage. 2016 Feb 19. pii: S1063-4584(16)01009-8. doi: 10.1016/j.joca.2015.11.023. [Epub ahead of print] Link to this article

Bastick AN, Wesseling J, Damen J, Verkleij SP, Emans PJ, Bindels PJ, Bierma-Zeinstra SM. Defining knee pain trajectories in early symptomatic knee osteoarthritis in primary care: 5-year results from a nationwide prospective cohort study (CHECK). Br J Gen Pract. 2016 Jan;66(642):e32-9. doi: 10.3399/bjgp15X688129. Epub 2015 Dec 6. Link to this article

van Spil WE, Agricola R, Drossaers-Bakker KW, Weinans H, Lafeber FP Associations of markers of matrix metabolism, inflammation markers, and adipokines with superior cam deformity of the hip and their relation with future hip osteoarthritis. Osteoarthritis Cartilage. 2015 Nov;23(11):1897-905. doi: 10.1016/j.joca.2015.03.026. Link to this article

Agricola R, Leyland KM, Bierma-Zeinstra SM, Thomas GE, Emans PJ, Spector TD, Weinans H, Waarsing JH, Arden NK. Validation of statistical shape modelling to predict hip osteoarthritis in females: data from two prospective cohort studies (Cohort Hip and Cohort Knee and Chingford). Rheumatology (Oxford). 2015 Jul 1. [Epub ahead of print]. Link to this article 

Wesseling J, Bastick AN, Ten Wolde S, Kloppenburg M, Lafeber FP, Bierma-Zeinstra SM, Bijlsma JW. Identifying Trajectories of Pain Severity in Early Symptomatic Knee Osteoarthritis: A 5-year Followup of the Cohort Hip and Cohort Knee (CHECK) Study. J Rheumatol. 2015 Jul 1. [Epub ahead of print]. Link to this article 

Van Spil WE, Welsing PM, Bierma-Zeinstra SM, Bijlsma JW, Roorda LD, Cats HA, Lafeber FP. The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK. Osteoarthritis Cartilage. 2015 [Epub ahead of print] Link to this article 

Agricola R, Waarsing JH, Thomas GE, Carr AJ, Reijman M, Bierma-Zeinstra SM, Glyn-Jones S, Weinans H, Arden NK. Response to letter to the editor: “Cam impingement: defining the presence of a cam deformity by the alpha angle data from the CHECK cohort an Chingford cohort”. Osteoarthritis Cartilage. 2014 Dec;22(12):2095-6. Epub 2014 Oct 6. Link to this article 

Van Spil WE, Nair SC, Kinds MB, Emans PJ, Hilberdink WK, Welsing PM, Lafeber FP. Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjects. Osteoarthritis Cartilage. 2014 Sep 6. [Epub ahead of print] Link to this article

Damen J, Schiphof D, Wolde S Ten, Cats HA, Bierma-Zeinstra SM, Oei EH. Inter-observer reliability for radiographic assessment of early osteoarthritis features: the CHECK (cohort hip and cohort knee) study.Osteoarthritis Cartilage. 2014 Jul;22(7):969-74. Epub 2014 May 21 Link to this article

Wesseling J, Boers M, Viergever MA, Hilberdink WK, Lafeber FP, Dekker J, Bijlsma JW. Cohort Profile: Cohort Hip and Cohort Knee (CHECK) study. Int J Epidemiol. 2014 Aug 29. [Epub ahead of print] Link to this article

Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, Roth J, van den Berg WB, van der Kraan PM, Blom AB, van Lent PL Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis. Ann Rheum Dis. 2014 Sep 1. [Epub ahead of print]. Link to this article

Ramos YF, Metrustry S, Arden N, Bay-Jensen AC, Beekman M, de Craen AJ, Cupples LA, Esko T, Evangelou E, Felson DT, Hart DJ, Ioannidis JP, Karsdal M, Kloppenburg M, Lafeber F, Metspalu A, Panoutsopoulou K, Slagboom PE, Spector TD, van Spil EW, Uitterlinden AG, Zhu Y; arcOGEN Consortium; TreatOA Collaborators, Valdes AM, van Meurs JB, Meulenbelt I. Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance. J Med Genet. 2014 Sep;51(9):596-604. doi: 10.1136/jmedgenet-2014-102478. Epub 2014 Jul 23. Link to this article

van der Esch M, Holla JF, van der Leeden M, Knol DL, Lems WF, Roorda LD, Dekker J Decrease of muscle strength is associated with increase of activity limitations in early knee osteoarthritis: 3-year results from the Cohort Hip and Cohort Knee study. Arch Phys Med Rehabil. 2014 Jun 27.[Epub ahead of print] Link to this article

Holla JF, van der Leeden M, Knol DL, Roorda LD, Hilberdink WK, Lems WF, Steultjens MP, Dekker J. Predictors and outcome of pain-related avoidance of activities in persons with early symptomatic knee osteoarthritis: A 5-year follow-up study. [Epub ahead of print] Link to this article

Damen J, Schiphof D, Wolde S Ten, Cats HA, Bierma-Zeinstra SM, Oei EH. Inter-observer reliability for radiographic assessment of early osteoarthritis features: the CHECK(cohort hip and cohort knee) study. Osteoarthritis Cartilage. 2014 May 21. [Epub ahead of print] Link to this article

de Klerk B, Lafeber FP, van Spil WE. Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: new insights from CHECK. Ann Rheum Dis. 2014 Jul;73(7):e39. Epub 2014 Apr 2. No abstract available. Link to this article

Holla JF, van der Leeden M, Heymans MW, Roorda LD, Bierma-Zeinstra SM, Boers M, Lems WF, Steultjens MP, Dekker J. Three trajectories of activity limitations in early symptomatic knee osteoarthritis: a 5-year follow-up study. Ann Rheum Dis. 2014 Jul;73(7):1369-75. Epub 2013 May 28. Link to this article

Agricola R, Waarsing JH, Thomas GE, Carr AJ, Reijman M, Bierma-Zeinstra SM, Glyn-Jones S, Weinans H, Arden NK. Cam impingement: defining the presence of a cam deformity by the alpha angle Data from the CHECK cohort and Chingford cohort. Osteoarthritis Cartilage. 2013 Nov 21. [Epub ahead of print]  Link to this article 

Wesseling J, Bierma-Zeinstra SM, Kloppenburg M, Meijer R, Bijlsma JW. Worsening of pain and function over 5 years in individuals with ‘early’ OA is related to structural damage: data from the Osteoarthritis Initiative and CHECK (Cohort Hip & Cohort Knee) study. Ann Rheum Dis. 2013 Nov 15. [Epub ahead of print] Link to this article

Agricola R, Heijboer MP, Roze RH, Reijman M, Bierma-Zeinstra SM, Verhaar JA, Weinans H, Waarsing JH. Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK).Osteoarthritis Cartilage. 2013 Oct;21(10):1514-21. Epub 2013 Jul 9.  Link to this article

Kinds MB, Marijnissen AC, Viergever MA, Emans PJ, Lafeber FP, Welsing PM. Identifying phenotypes of knee osteoarthritis by separate quantitative radiographic features may improve patient selection for more targeted treatment. J Rheumatol. 2013 Jun;40(6):891-902. Epub 2013 May 1. Link to this article

Agricola R, Waarsing JH, Arden NK, Carr AJ, Bierma-Zeinstra SM, Thomas GE, Weinans H, Glyn-Jones S. Cam impingement of the hip–a risk factor for hip osteoarthritis. Nat Rev Rheumatol. 2013 Oct;9(10):630-4. Epub 2013 Jul 23. Link to this article

Agricola R, Reijman M, Bierma-Zeinstra SM, Verhaar JA, Weinans H, Waarsing JH. Total hip replacement but not clinical osteoarthritis can be predicted by the shape of the hip: a prospective cohort study (CHECK).Osteoarthritis Cartilage. 2013 Apr;21(4):559-64. Epub 2013 Jan 17. Link to this article 

Vos PA, Welsing PM, Degroot J, Huisman AM, Oostveen JC, Reijman M, Damen J, Mastbergen SC, Lafeber FP. Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up. Osteoarthritis Cartilage. 2013 Mar 27. Link to this article

Bieleman HJ, Reneman MF, Drossaers-Bakker KW, Groothoff JW, Oosterveld FG. Prognostic factors for sustained work participation in early osteoarthritis: a follow-up study in the Cohort Hip and Cohort Knee (CHECK). J Occup Rehabil. 2013 Mar;23(1):74-81. Link to this article 

Wesseling J, Welsing PM, Bierma-Zeinstra SM, Dekker J, Gorter KJ, Kloppenburg M, Roorda LD, Bijlsma JW. Impact of self-reported comorbidity on physical and mental health status in early symptomatic osteoarthritis: the CHECK (Cohort Hip and Cohort Knee) study. Rheumatology (Oxford). 2013 Jan;52(1):180-8. Epub 2012 Oct 23. Link to this article 

Kinds MB, Marijnissen AC, Bijlsma JW, Boers M, Lafeber FP, Welsing PM. Quantitative radiographic features of early knee osteoarthritis: development over 5 years and relationship with symptoms in the CHECK cohort. J Rheumatol. 2013 Jan;40(1):58-65. Epub 2012 Nov 1. Link to this article 

van Spil WE, Drossaers-Bakker KW, Lafeber FP. Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis. Ann Rheum Dis. 2013 Jan;72(1):29-36. Epub 2012 Jun 11. Link to this article 

Van Spil WE, Welsing PM, Kloppenburg M, Bierma-Zeinstra SM, Bijlsma JW, Mastbergen SC, Lafeber FP. Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK. Osteoarthritis Cartilage. 2012 Nov;20(11):1278-85. Epub 2012 Aug 10. Link to this article 

Holla JF, van der Leeden M, Peter WF, Roorda LD, van der Esch M, Lems WF, Gerritsen M, Voorneman RE, Steultjens MP, Dekker J. Proprioception, laxity, muscle strength and activity limitations in early symptomatic knee osteoarthritis: results from the CHECK cohort. J Rehabil Med. 2012 Oct;44(10):862-8. Link to this article 

van Spil WE, Jansen NW, Bijlsma JW, Reijman M, DeGroot J, Welsing PM, Lafeber FP. Clusters within a wide spectrum of biochemical markers for osteoarthritis: data from CHECK, a large cohort of individuals with very early symptomatic osteoarthritis. Osteoarthritis Cartilage. 2012 Jul;20(7):745-54. Epub 2012 Apr 11. Link to this article 

Agricola R, Heijboer MP, Bierma-Zeinstra SM, Verhaar JA, Weinans H, Waarsing JH. Cam impingement causes osteoarthritis of the hip: a nationwide prospective cohort study (CHECK). Ann Rheum Dis. 2012 Jun 23. Link to this article

Kinds MB, Marijnissen AC, Vincken KL, Viergever MA, Drossaers-Bakker KW, Bijlsma JW, Bierma-Zeinstra SM, Welsing PM, Lafeber FP. Evaluation of separate quantitative radiographic features adds to the prediction of incident radiographic osteoarthritis in individuals with recent onset of knee pain: 5-year follow-up in the CHECK cohort. Osteoarthritis Cartilage. 2012 Jun;20(6):548-56. Epub 2012 Feb 22. Link to this article

Hoogeboom TJ, Snijders GF, Cats HA, de Bie RA, Bierma-Zeinstra SM, van den Hoogen FH, van Riel PL, Emans PJ, Wesseling J, den Broeder AA, van den Ende CH. Prevalence and predictors of health care use in patients with early hip or knee osteoarthritis: two-year follow-up data from the CHECK cohort. Osteoarthritis Cartilage. 2012 Jun;20(6):525-31. Epub 2012 Mar 16. Link to this article 

Kinds MB, Vincken KL, Hoppinga TN, Bleys RL, Viergever MA, Marijnissen AC, Welsing PM, Lafeber FP.Influence of variation in semiflexed knee positioning during image acquisition on separate quantitative radiographic parameters of osteoarthritis, measured by Knee Images Digital Analysis. Osteoarthritis Cartilage. 2012 Apr 26. Link to this article

Holla JF, van der Leeden M, Knol DL, Peter WF, Roorda LD, Lems WF, Wesseling J, Steultjens MP, Dekker J.Avoidance of Activities in Early Symptomatic Knee Osteoarthritis: Results from the CHECK Cohort. Ann Behav Med. 2012 Mar 13. Link to this article

Holla JF, van der Leeden M, Roorda LD, Bierma-Zeinstra SM, Damen J, Dekker J, Steultjens MP. Diagnostic accuracy of range of motion measurements in early symptomatic hip and/or knee osteoarthritis. Arthritis Care Res (Hoboken). 2012 Jan;64(1):59-65. Link to this article

van Lent P, Blom A, Schelbergen R, Sloetjes A, Lafeber F, Lems W, Cats H, Vogl T, Roth J, van den Berg W Active involvement of “alarmins” S100A8 and S100A9 in regulation of synovial activation and joint destruction during mouse and human osteoarthritis. Arthritis Rheum. 2011 Dec 5.  Link to this article

Kinds M, Vincken K, Vignon E, Wolde ST, Bijlsma J, Welsing P, Marijnissen A, Lafeber F. Radiographic features of knee and hip osteoarthritis represent characteristics of an individual, in addition to severity of osteoarthritis. Scand J Rheumatol. 2011 Dec 16. Link to this article

Bieleman HJ, Bierma-Zeinstra SM, Oosterveld FG, Reneman MF, Verhagen AP, Groothoff JW. The effect of osteoarthritis of the hip or knee on work participation. J Rheumatol. 2011 Sep;38(9):1835-43. Epub 2011 Jun 15. Link to this article 

Holla JF, van der Leeden M, Roorda LD, Bierma-Zeinstra SM, Damen J, Dekker J, Steultjens MP. Diagnostic accuracy of range of motion measurements in early symptomatic hip and/or knee osteoarthritis: Results from the CHECK cohort. Arthritis Care Res (Hoboken). 2011 Sep 27. Link to this article

Kinds MB, Bartels LW, Marijnissen AC, Vincken KL, Viergever MA, Lafeber FP, de Jong HW.Feasibility of bone density evaluation using plain digital radiography. Osteoarthritis Cartilage. 2011 Nov;19(11):1343-8. Epub 2011 Aug 17. Link to this article

Kinds MB, Welsing PM, Vignon EP, Bijlsma JW, Viergever MA, Marijnissen AC, Lafeber FP.A systematic review of the association between radiographic and clinical osteoarthritis of hip and knee. Osteoarthritis Cartilage. 2011 Jul;19(7):768-78. Epub 2011 Jan 31. Review. Link to this article 

Holla JF, Steultjens MP, van der Leeden M, Roorda LD, Bierma-Zeinstra SM, den Broeder AA, Dekker J.Determinants of range of joint motion in patients with early symptomatic osteoarthritis of the hip and/or knee: an exploratory study in the CHECK cohort. Osteoarthritis Cartilage. 2011 Jan 25. Link to this article 

Vos PA, Degroot J, Huisman AM, Oostveen JC, Marijnissen AC, Bijlsma JW, van El B, Zuurmond AM, Lafeber FP. Skin and urine pentosidine weakly correlate with joint damage in a cohort of patients with early signs of osteoarthritis (CHECK). Osteoarthritis Cartilage. 2010 Jul 29. [Epub ahead of print] Link to this article

Holla JF, Steultjens MP, Roorda LD, Heymans MW, Ten Wolde S, Dekker J. Prognostic factors for the two-year course of activity limitations in early osteoarthritis of the hip and/or knee: Results from the CHECK cohort. Arthritis Care Res (Hoboken). 2010 May 23. [Epub ahead of print] Link to this article

van Spil WE, DeGroot J, Lems WF, Oostveen JC, Lafeber FP. Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria. Osteoarthritis Cartilage 2010 May;18(5):605-12. Epub 2010 Feb 6. Link to this article

Bieleman HJ, van Ittersum MW, Groothoff JW, Oostveen JC, Oosterveld FG, van der Schans CP, Soer R, Reneman MF Functional capacity of people with early osteoarthritis: a comparison between subjects from the cohort hip and cohort knee (CHECK) and healthy ageing workers. Int Arch Occup Environ Health. 2010 May 21. [Epub ahead of print] Link to this article 

Bieleman H, Oosterveld F, Oostveen J, Reneman M, Groothoff J. Work participation and health status in early osteoarthritis of hip and/or knee: a comparison between Cohort Hip and Cohort Knee (CHECK) and Osteoarthritis Initiative (OAI). Arthritis Care Res (Hoboken). 2010 Jan 29. Link to this article 

Bieleman HJ, Reneman MF, van Ittersum MW, van der Schans CP, Groothoff JW, Oosterveld FG. Self-reported functional status as predictor of observed functional capacity in subjects with early osteoarthritis of the hip and knee: a diagnostic study in the CHECK cohort. J. Occup Rehabil. 2009 Dec; 19(4):345-53. Epub 2009 Jun 26. Link to this article

van Ittersum MW, Bieleman HJ, Reneman MF, Oosterveld FG, Groothoff JW, van der Schans CP. Functional capacity evaluation in subjects with early osteoarthritis of hip and/or knee; is two-day testing needed?J Occup Rehabil. 2009 Sep;19(3):238-44. Epub 2009 May 15. Link to this article

Wesseling J, Dekker J, van den Berg WB, Bierma-Zeinstra SM, Boers M, Cats HA, Deckers P, Gorter KJ, Heuts PH, Hilberdink WK, Kloppenburg M, Nelissen RG, Oosterveld FG, Oostveen JC, Roorda LD, Viergever MA, ten Wolde S, Lafeber FP, Bijlsma JW. CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative. Ann Rheum Dis. 2009 Sep;68(9):1413-9. Epub 2008 Sep 4. Link to this article