Welcome, this website provides access to the CHECK study documentation and data

In the Netherlands, a multi centre cohort was formed by the Dutch Arthritis Foundation (DAF) with over 1000 participants with symptomatic osteoarthritis of hip and/or knee: CHECK (Cohort Hip & Cohort Knee). The objective of CHECK is to study the course of complaints, the mechanisms that cause joint damage, and to identify markers for diagnosis and prognosis, as well as to identify prognostic factors that predict and explain the course of OA.

Participants visited the hospital every year and the following data and materials were gathered.

CHECK circle

 

Measurement Frequency of examinations
T0 T1 T2 T3 T4 T5 T6 T7 T8 T9 T10
baseline After 1 year After 2 years After 3 years After 4 years After 5 years After 6 years After 7 years After 8 years After 9 years After 10 years
Questionnaire
All questionnaires are centrally collected and checked by data manger on missing data, inconsistency, and out of order range. If possible, missing data are traced. Each 3 months the institutes are visited by a single central coordinator to support complete and accurate data gathering.
Demographics
Involvement in life situation: employment, current and past
SF36: short Form 36-item status survey
EQ5D: EuroQol
WOMAC: Western Ontario and McMaster University
AUSCAN: Australien Canadian OA Hand index
ICOAP: Measure of Intermittent and Constant OA pain
Numeric Rating Scale for pain intensity
Comorbidity list
Health care use
Pain Coping Inventary list
Social Support scale
Lifestyle: tobacco and alcohol use
Clinical data
All case report forms are centrally collected and checked by data manger on missing data, inconsistency, and out of order range. If possible, missing data are traced, out of order and inconsistency data are checked by physician who performed the physical examination. All physician performed physical examination according to a standardised protocol, are trained by a single central coordinator and each year their physical examination is evaluated.
Knee examination
• Palpable warmth
• Refill test
• Bony tenderness
• Patella grinding test
• Range of Motion- flexion/ extension
• Crepitus
Hip examination
• Range of motion- flexion/internal/external rotation/ adduction/abduction
Hand examination
• DIP/ PIP bony enlargements
• CMC I bony enlargements
• Soft tissue swelling MCP I-V
• Deformity CMC I, DIP, PIP
Images: X ray
All X-rays are centrally collected and stored. Radiographic technician performed the CHECK images according to a standardized protocol, are trained by a single central coordinator and each year their performance is evaluated
Knee: unilateral PA fixed flexion view (both knees)
Knee: unilateral lateral view (both knees)
Knee: bilateral skyline view (supine)
Hip: AP pelvis view
Hip: unilateral faux profile view (both hips)
Hand: bilateral PA view
Lumbar spine: lateral view (supine)
Blood collection
All blood samples are centrally collected, worked up into vials for storage in -80°C or -20°C according to a standardized protocol. Each year internal and external audits take place to evaluate the proceedings.
8x 750µl  serum
12x 750µl plasma
4x 750µl plasma
4x 750µl serum
2x 750µl mononuclear cell DNA
Urine collection
All urine samples are centrally collected, worked up into vials for storage in -80°C or -20°C according to a standardized protocol. Each year internal and external audits take place to evaluate the proceedings.
6x 5 ml urine
4x 5 ml urine

Data

dropout2016